diff options
| author | muqiuhan <[email protected]> | 2025-10-28 11:11:04 +0000 |
|---|---|---|
| committer | muqiuhan <[email protected]> | 2025-10-28 11:11:04 +0000 |
| commit | c8b9d15b35905aab0a85a1a8085d0a0f460e732f (patch) | |
| tree | 5d4993e22e62183af86970445abf8e59bb14218b /2025/10/24/Neutrophils-are-a-double-edged-sword | |
| parent | 551532fc3058499944183c501459fa7f738ce232 (diff) | |
| download | blog-c8b9d15b35905aab0a85a1a8085d0a0f460e732f.tar.gz | |
deploy: f2e4dd27edd32f0c4cc42e7b711660e331bdbb73
Diffstat (limited to '2025/10/24/Neutrophils-are-a-double-edged-sword')
| -rw-r--r-- | 2025/10/24/Neutrophils-are-a-double-edged-sword/index.html | 2 |
1 files changed, 0 insertions, 2 deletions
diff --git a/2025/10/24/Neutrophils-are-a-double-edged-sword/index.html b/2025/10/24/Neutrophils-are-a-double-edged-sword/index.html index 99cce419..d56b9a6d 100644 --- a/2025/10/24/Neutrophils-are-a-double-edged-sword/index.html +++ b/2025/10/24/Neutrophils-are-a-double-edged-sword/index.html @@ -207,8 +207,6 @@ <p>这些细胞在肺泡和支气管黏膜定植后，释放MMP-9（促进基质降解和气道重构）、弹性蛋白酶（破坏弹性纤维，导致肺气肿）和LTB4（进一步放大炎症级联）。</p> <p>而 PDE4（磷酸二酯酶4）能够降解cAMP（环腺苷酸），从而增强中性粒细胞的趋化、脱颗粒和ROS产生。</p> <p>所以临床上，PDE4 抑制剂如罗氟司特（roflumilast）被批准用于重度COPD，以降低中性粒细胞介导的炎症，减少急性加重风险。</p> -<p>同时，B细胞和T细胞的交互可间接放大中性粒细胞响应，而MMP-9的升高则与COPD进展相关，血清水平可作为生物标志物监测疾病严重度。</p> -<p>总体而言，在COPD中，中性粒细胞从毒性释放加剧了气道阻塞、肺功能下降和共病风险，如心血管事件。</p> </div> |