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Fever of unknown origin (FUO) has been recognized as a disease state for over
100 years. The first commonly accepted definition of FUO was published in 1961
and included (1) fever greater than 101 F (38.3 C) on multiple occasions (2) at least
3 week duration of fever (3) without identifiable cause despite at least a 1 week inpa-
tient evaluation.1 Overtime, this definition was considered both too rigid and too ill
defined. Given the impracticality of prolonged hospitalizations and advancing technol-
ogy for diagnosis, the duration of work up was shortened to 3 days inpatient evaluation
and/or 3 outpatient clinic visits.2

+

Fever of unknown origin (FUO) has been recognized as a disease state for over100 years.
The first commonly accepted definition of FUO was published in 1961 and included fever greater than 101F (38.3C) on multiple occasions at least 3 week duration of fever without identifiable cause despite at least a 1 week inpatient evaluation.

+

Overtime, this definition was considered both too rigid and too ill defined.
Given the impracticality of prolonged hospitalizations and advancing technology for diagnosis, the duration of work up was shortened to 3 days inpatient evaluation and/or 3 outpatient clinic visits.

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