二〇二六年四月二十一日

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+---
+title: Fever of Unknown Origin
+date: 2023-11-16 07:04:44
+tags: Medicine
+---
+
+
+Fever of unknown origin (FUO) has been recognized as a disease state for over100 years.
+The first commonly accepted definition of FUO was published in 1961 and included fever greater than 101F (38.3C) on multiple occasions at least 3 week duration of fever without identifiable cause despite at least a 1 week inpatient evaluation.
+
+Overtime, this definition was considered both too rigid and too ill defined.
+Given the impracticality of prolonged hospitalizations and advancing technology for diagnosis, the duration of work up was shortened to 3 days inpatient evaluation and/or 3 outpatient clinic visits.
+
+- [Original Document](/papers/Fever%20of%20Unknown%20Origin.pdf)
+
+这是FUO(不明原因发烧)的综合指南，第一个普遍接受的 FUO 定义是1961 年发布的，包括多次发烧超过三十八度三，发烧持续时间至少 3 周，并且就算住院至少 1 周但仍无明确原因。后面这个定义被认为过于僵化且过于模糊。又改成了三天住院评估和/或三次门。除了有关评估持续时间的所有时间要求，还应该将 FUO 定义为完成最低限度检查后缺乏已知病因的发烧。
+
+常见原因就感染性，自身免疫和结缔组织疾病，其他炎症过程和恶性肿瘤。结缔组织疾病和自身免疫性疾病是青少年 FUO 比儿童更常见的原因。
+总体上有超过两百种病因可导致 FUO
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